Benzoic Acids, Benzamides and Toluenes in the Rabbit by H. G. Bray, Brenda

The previous papers of this series (Bray, Thorpe & White, 1951, 1952e; Bray, Humphris, Thorpe, White & Wood, 1952b, c, d) reported a study of the kinetics in vivo of some reactions involving benzoic acid and some of its precursors, certain precursors of phenols and a series of substituted phenols. A mathematical model was worked out which could account for the effect upon metabolic fate of dose level, nuclear substituents, quantitative differences between the metabolism of precursors and their conversion products, and species differences. These investigations have now been extended by studying the metabolism in the rabbit of various nuclear substituted toluenes, benzamides and benzoic acids. It has been found that the metabolic processes involved follow kinetics similar to those already reported and values are given for the appropriate velocity constants. There appeared to be no correlation between these values and the size or electronic nature of the substituents.